Northern China is the natural habitat of the Schisandra plant (Schisandra Chinensis). In addition to its culinary and Schisandra benefits, the fruit is also consumed.
In this way, Schisandra functions as an adaptogen. Natural compounds known as adaptogens are thought to increase resilience to mental, physiological, and environmental stress effects. Chemicals in Schisandra may increase energy and boost endurance and coordination by enhancing liver function.
Despite widespread anecdotal reports of success, there is currently no solid scientific evidence to support the use of Schisandra for anything, including menopause, exercise performance, or pneumonia.
Special Precautions and Warnings
When appropriately used, Schisandra may be safe for oral consumption. It has been tested for up to 12 weeks with no adverse effects. Acid reflux, nausea, vomiting, loss of appetite, and hives are all possible side effects. Schisandra may not be safe for pregnant women to ingest orally. A miscarriage could result from the uterus contracting as a result of this. If you’re pregnant, you shouldn’t take Schisandra.
For the time being, we cannot confidently say that Schisandra is safe to take while breastfeeding. To be on the safe side, refrain from using.
Interactions
Conversational Pace
We would advise caution when using this pairing.
Interactions with SCHISANDRA and drugs metabolized by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Sometimes, the liver is responsible for metabolizing and altering the drug. A potential effect of Schisandra on the rate at which the liver metabolizes certain drugs also exists. Both the benefits and risks of these drugs may be affected.
SCHISANDRA interacts with drugs metabolized by the liver (Cytochrome P450 3A4 (CYP3A4) substrates).
The liver is responsible for metabolizing and transforming some drugs. The rate at which the liver processes these drugs may be altered by Schisandra. This can potentially change these drugs’ therapeutic and adverse effects.
Interaction Between Tacrolimus (Prograf) and SCHISANDRA
The rate of tacrolimus breakdown could be slowed by Schisandra. Both the benefits and risks of tacrolimus may be amplified if taken alongside Schisandra. Before beginning treatment with this mixture, discuss it with your doctor.
SCHISANDRA has an interaction with the blood thinner warfarin (Coumadin).
To prevent excessive clotting, warfarin is taken. Schisandra could reduce the effectiveness of warfarin by increasing its breakdown. Reduced warfarin effectiveness may raise the risk of blood clots. Maintain consistent blood testing. Your warfarin dosage may need to be adjusted.
This interaction between SCHISANDRA and midazolam
Schisandra may slow down the rate at which midazolam is metabolized. It’s possible that combining Schisandra with midazolam would heighten the latter’s sedative effects and toxicity.
Talinolol is SCHISANDRA-interactive.
Possible upregulation of talinolol levels by Schisandra. Talinolol’s effects and adverse effects could be amplified by the concurrent use of Schisandra.
SCHISANDRA binds to drugs transported by cell pumps (P-glycoprotein substrates).
Pumps are used to transfer some drugs into and out of cells. Schisandra extract can affect the performance of these pumps and the amount of medication retained in the body. This could modify a drug’s effects and side effects in certain situations.
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This study found that the antifungal drug voriconazole (Vfend) interacted with the SCHISANDRA.
Schisandra could slow down the rate at which voriconazole is metabolized. It is possible that the effectiveness and toxicity of voriconazole would be amplified when combined with Schisandra.
SCHISANDRA interacts with drugs metabolized by the liver (Cytochrome P450 2C19 (CYP2C19) substrates).
The liver is responsible for metabolizing and transforming some drugs. The rate at which the liver processes these drugs may be altered by Schisandra. This can potentially change these drugs’ therapeutic and adverse effects.
Sirolimus (Rapamune) interacts with SCHISANDRA.
Schisandra may slow down the rate at which sirolimus is metabolized. When used with sirolimus, Schisandra may increase the drug’s efficacy and toxicity. If you are considering taking sirolimus, you should consult your doctor first.